Costa C M, de Camargo B, Bagietto R, Alcantra P S, Chojniak R, Sredni S T
Department of Pediatric Oncology, Hospital do Cancer A. C. Camargo, Sao Paulo, Brazil.
J Pediatr Hematol Oncol. 1998 May-Jun;20(3):271-3. doi: 10.1097/00043426-199805000-00017.
Nonpulmonary metastases from osteogenic sarcoma are rare. A patient had a localized osteogenic sarcoma of the left femur which recurred in the abdomen, a previously unreported metastatic site.
An 18-year-old boy was treated for osteosarcoma. He had abdominal pain, vomiting, weight loss, and symptoms of intestinal obstruction at the time of relapse.
The patient had diffuse widespread intraabdominal osteogenic sarcoma as the only site of initial recurrence. Abdominal computerized tomography revealed ascites and calcified masses on the hepatic and peritoneal surfaces. Laparoscopic visualization of the abdomen showed hemorrhagic ascites and multiple calcified tumor on the peritoneum, diaphragm, and liver. A biopsy of a representative lesion confirmed the diagnosis of osteogenic sarcoma. The patient died from progressive disease.
As the initial treatment for patients with osteogenic sarcoma is intensified, the pattern of metastases may change. Unusual sites of recurrence such as in this patient may become more prevalent. A clinical presentation of an acute abdomen in a patient previously treated for osteogenic sarcoma should prompt suspicion of intraabdominal recurrence.
骨肉瘤的非肺转移罕见。一名患者左股骨发生局限性骨肉瘤,其复发于腹部,这是一个此前未报道过的转移部位。
一名18岁男孩接受骨肉瘤治疗。复发时他出现腹痛、呕吐、体重减轻及肠梗阻症状。
患者最初复发的唯一部位是弥漫性广泛的腹腔内骨肉瘤。腹部计算机断层扫描显示腹水以及肝脏和腹膜表面的钙化肿块。腹腔镜检查可见腹腔内有血性腹水,腹膜、膈肌和肝脏上有多个钙化肿瘤。对一个典型病变进行活检确诊为骨肉瘤。患者死于疾病进展。
随着骨肉瘤患者初始治疗强度的增加,转移模式可能会改变。像该患者这样不寻常的复发部位可能会变得更加常见。既往接受过骨肉瘤治疗的患者出现急腹症临床表现时,应怀疑腹腔内复发。