Voyno-Yasenetskaya T A
Department of Pharmacology, University of Illinois at Chicago College of Medicine 60612-7343, USA.
Biol Signals Recept. 1998 Mar-Apr;7(2):118-24. doi: 10.1159/000014537.
The Na+/H+ exchangers are important regulators of intracellular pH, cell volume, and cell proliferation. They exist in all cells with a cell-specific pattern of isoform expression. Na+/H+ exchangers are regulated by a variety of extracellular stimuli which activate G-protein-coupled receptors and receptor tyrosine. Heterotrimeric G proteins regulated distinct signaling pathways, some of which in turn regulate the activity of Na+/H+ exchangers. This review describes the recent findings concerning the molecular mechanisms of the G-protein-dependent regulation of Na+/H+ exchangers.
钠/氢交换体是细胞内pH值、细胞体积和细胞增殖的重要调节因子。它们存在于所有细胞中，具有细胞特异性的同工型表达模式。钠/氢交换体受多种细胞外刺激的调节，这些刺激激活G蛋白偶联受体和受体酪氨酸。异源三聚体G蛋白调节不同的信号通路，其中一些信号通路反过来又调节钠/氢交换体的活性。本综述描述了关于G蛋白依赖性调节钠/氢交换体分子机制的最新发现。
