Zhang Y Y, Bailey R R
Department of Nephrology, Christchurch Hospital, New Zealand.
Pediatr Nephrol. 1998 Apr;12(3):190-6; discussion 189. doi: 10.1007/s004670050435.
Eighteen Coopworth ewe lambs were divided into three groups based on the initial cystourethrogram and cystometry findings at 5-7 weeks of age: group 1, 6 lambs with spontaneous low-pressure bilateral vesicoureteric reflux (VUR) on bladder filling were used to study the natural history of reflux; group 2, 5 lambs with no VUR detected were used to establish an experimental model of bilateral VUR using an unroofing surgical procedure; group 3, 7 lambs with spontaneous VUR detected during micturition had the same surgical procedure to increase the degree of VUR. All three animal groups were followed for 4-10 months. Spontaneous VUR was demonstrated in 13 of 18 lambs (25/36 ureters). The presence and severity of spontaneously occurring reflux in group 1 lambs diminished with increasing age. VUR was created successfully in group 2 and increased in degree in group 3 animals. The only significant histological finding in all three animal groups with grades II and III VUR was distal renal tubular dilatation. The sheep is a useful and readily available animal for studying VUR. During 4-10 months of follow-up, sterile reflux without bladder outflow obstruction resulted in distal renal tubular dilatation, but no renal parenchymal damage.
18只库泊华斯母羊羔在5至7周龄时根据初始膀胱尿道造影和膀胱测压结果分为三组：第1组，6只在膀胱充盈时出现自发性低压双侧膀胱输尿管反流（VUR）的羊羔用于研究反流的自然病程；第2组，5只未检测到VUR的羊羔用于通过去顶手术建立双侧VUR的实验模型；第3组，7只在排尿时检测到自发性VUR的羊羔接受相同手术以增加VUR程度。所有三个动物组均随访4至10个月。18只羊羔中有13只（36条输尿管中的25条）出现自发性VUR。第1组羊羔中自发反流的存在和严重程度随年龄增长而减轻。第2组成功创建了VUR，第3组动物的VUR程度增加。在所有三个患有II级和III级VUR的动物组中，唯一显著的组织学发现是远端肾小管扩张。绵羊是研究VUR的一种有用且易于获得的动物。在4至10个月的随访期间，无膀胱流出道梗阻的无菌反流导致远端肾小管扩张，但无肾实质损伤。
