Gibson E, Fleming N, Fleming D, Culhane J, Hauck F, Janiero M, Spitzer A
Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA.
Med Care. 1998 Jun;36(6):938-42. doi: 10.1097/00005650-199806000-00017.
In April 1992, the American Academy of Pediatrics (AAP) recommended that healthy infants be positioned for sleep on their side or back to reduce the risk of Sudden Infant Death Syndrome (SIDS). The authors hypothesized three different forms of the intervention to examine the impact of the recommendation according to theory such as technology diffusion. Seasonality was included in the models to control its effect when testing.
Box and Tiao time-series intervention methodology was used to examine the effect of the AAP recommendation on SIDS rates. Sudden Infant Death Syndrome mortality data from Philadelphia and Chicago were examined separately for white and nonwhite populations over 32 quarters.
Overall SIDS rates dropped significantly according to an abrupt effect from the intervention. However, the effect appeared to be gradually declining in Philadelphia but permanent in Chicago. In Philadelphia, a decline of 62.3% was estimated in whites in the first quarter after the intervention but decreased to only 5% in the last quarter of 1994. A decline of 35.8% was estimated in nonwhites in the first quarter after the intervention but decreased to only 9.4% in the last quarter of 1994. An abrupt and permanent decrease of 26.7% and 16.5% was found in Chicago for whites and nonwhites, respectively.
Evidence of an abrupt adoption of the recommendation can be explained by the authority innovation decision made by the AAP. Some evidence was found that the effect is temporary, perhaps because physicians are reversing earlier decisions. The demonstrated methodology provides a powerful way to test naturally occurring interventions from quasiexperimental designs to test the impact of policy guidelines.
1992年4月,美国儿科学会(AAP)建议健康婴儿应以侧卧或仰卧姿势睡眠,以降低婴儿猝死综合征(SIDS)的风险。作者假设了三种不同形式的干预措施,以便根据技术传播等理论来检验该建议的影响。在测试时,模型中纳入了季节性因素以控制其影响。
采用Box和Tiao时间序列干预方法来检验AAP建议对SIDS发生率的影响。分别对费城和芝加哥32个季度的白人及非白人人口的婴儿猝死综合征死亡率数据进行了研究。
总体而言,SIDS发生率因干预措施产生的突然影响而显著下降。然而,在费城,这种影响似乎在逐渐减弱,而在芝加哥则是永久性的。在费城,干预后的第一季度,白人的SIDS发生率估计下降了62.3%,但到1994年最后一个季度仅降至5%。干预后的第一季度,非白人的SIDS发生率估计下降了35.8%,但到1994年最后一个季度仅降至9.4%。在芝加哥,白人及非白人的SIDS发生率分别突然且永久性地下降了26.7%和16.5%。
该建议被迅速采纳的证据可以通过AAP做出的权威性创新决策来解释。发现有一些证据表明这种影响是暂时的,可能是因为医生们正在推翻早期的决定。所展示的方法提供了一种强有力的方式,可从准实验设计中测试自然发生的干预措施,以检验政策指南的影响。