Erdogdu G, Hasirci V
Higher Education Council of Turkey, Bilkent, Ankara.
Environ Res. 1998 Jul;78(1):38-42. doi: 10.1006/enrs.1998.3842.
Asbestosis and silicosis are fibrotic diseases initiated by the inhalation of silica-containing dusts, asbestos and quartz. There are various approaches for explaining the causes of these diseases. At present, our knowledge on the matter indicates that silicic acid dissolved from these minerals, contact between macrophages and minerals, highly reactive and oxidative species formed on the mineral surface, and lysosomal enzymes released upon engulfment of particulate mineral of appropriate size all contribute to various extents to the initiation of fibrosis. Among these mineral solubility seems to have a substantial contribution as a causative factor.
石棉沉着病和矽肺病是因吸入含硅粉尘、石棉和石英而引发的纤维化疾病。对于这些疾病的病因有多种解释途径。目前，我们在这方面的知识表明，从这些矿物质中溶解出的硅酸、巨噬细胞与矿物质之间的接触、在矿物质表面形成的高活性氧化物质以及吞噬适当大小的颗粒状矿物质时释放的溶酶体酶，都在不同程度上促成了纤维化的起始。在这些因素中，矿物质的溶解度作为一个致病因素似乎起着重要作用。
