Noguchi K, Saito H, Abe K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113, Japan.
Brain Res. 1998 May 25;794(1):151-4. doi: 10.1016/s0006-8993(98)00210-8.
We have previously found that high-frequency stimulation of the medial amygdala (MeA) induces long-term potentiation (LTP) of the population spike in the perforant path-dentate granule cell synapses of anesthetized rats. In the present study, we investigated the influence of MeA stimulation on the relationship between the population excitatory postsynaptic potential (pEPSP) and population spike in the dentate gyrus. High-frequency stimulation of the MeA produced a leftward shift of the E-S curve, in which population spike amplitude was plotted against pEPSP slope at various stimulus intensities. MeA-induced population spike LTP was also observed under blockade of GABAergic inhibition with picrotoxin. These results suggests that MeA stimulation leads to a long-lasting change in the internal firing characteristics of the dentate granule cells.
我们之前发现，高频刺激内侧杏仁核（MeA）可诱导麻醉大鼠的穿通通路-齿状颗粒细胞突触群体峰电位产生长时程增强（LTP）。在本研究中，我们研究了MeA刺激对齿状回中群体兴奋性突触后电位（pEPSP）与群体峰电位之间关系的影响。高频刺激MeA使E-S曲线向左移位，其中群体峰电位幅度是针对不同刺激强度下的pEPSP斜率绘制的。在用印防己毒素阻断GABA能抑制的情况下，也观察到了MeA诱导的群体峰电位LTP。这些结果表明，MeA刺激导致齿状颗粒细胞的内在放电特性发生持久变化。
