Endo H, Sasaki K, Tonosaki A, Kayama T
Department of Neurosurgery, Yamagata University, School of Medicine, Yamagata, Japan.
Brain Res. 1998 May 18;793(1-2):297-301. doi: 10.1016/s0006-8993(98)00042-0.
To investigate immunological environment in the cerebrospinal fluid (CSF) system, ultrastructural and three-dimensional localization of intercellular adhesion molecule-1 (ICAM-1) was studied in the choroid plexus, arachnoid membrane and dural sinus of LPS-stimulated rats with immuno-SEM and TEM. The choroid plexus epithelial cells expressed rich ICAM-1 along the microvilli. The arachnoid trabeculae fibroblast-like cells demonstrated ICAM-1 expression on both sides facing the subarachnoid space moderately. The dural sinus endothelial cells, however, showed only few ICAM-1 expression and no specific localization. These results suggest that the choroid plexus and arachnoid membrane may play an important mutual role for leukocyte migration in the CSF system, and that the CSF system may function in immunoreaction independently of the vascular system with the aid of up-regulated ICAM-1 expression.
为研究脑脊液（CSF）系统中的免疫环境，采用免疫扫描电子显微镜（immuno-SEM）和透射电子显微镜（TEM），对脂多糖（LPS）刺激大鼠的脉络丛、蛛网膜和硬脑膜窦中细胞间粘附分子-1（ICAM-1）进行超微结构和三维定位研究。脉络丛上皮细胞沿微绒毛表达丰富的ICAM-1。蛛网膜小梁成纤维细胞样细胞在面向蛛网膜下腔的两侧均有中度ICAM-1表达。然而，硬脑膜窦内皮细胞仅显示少量ICAM-1表达且无特异性定位。这些结果表明，脉络丛和蛛网膜可能在CSF系统中白细胞迁移方面发挥重要的相互作用，并且CSF系统可能借助上调的ICAM-1表达在免疫反应中独立于血管系统发挥作用。
