信号转导抑制剂，小双孢菌产生的hibarimicins A、B、C、D和G。II. 结构研究。
Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural studies.
作者信息
Hori H, Igarashi Y, Kajiura T, Furumai T, Higashi K, Ishiyama T, Uramota M, Uehara Y, Oki T
机构信息
Faculty of Agriculture, Tamagawa University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1998 Apr;51(4):402-17. doi: 10.7164/antibiotics.51.402.
PMID:9630862
Abstract
The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.
摘要
利用光谱技术确定了作为酪氨酸特异性蛋白激酶抑制剂的日巴霉素A、B、C、D和G的结构。本报告中描述的日巴霉素由一个共同的苷元和六个脱氧己糖组成。苷元含有一个高度氧化的萘基萘醌作为发色团。其中，日巴霉素B与当归霉素B相同。
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