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[通过在氧化亚铁存在下的化学发光测定抗氧化剂在脂质体系中的作用机制]

[Determination of the mechanism of action of antioxidants in lipid systems from chemiluminescence in the presence of ferrous oxide].

作者信息

Vladimirov Iu A, Petrenko Iu M

出版信息

Biofizika. 1976 May-Jun;21(3):424-7.

PMID:963089
Abstract

Different action mechanisms of antioxidants affecting various stages of chemoluminescence developing in the lipid systems with ferrous ions are considered theoretically. Experimental studies are carried out on beta-naphtol and 5-oxitriptamine--antioxidants whose action mechanism in other systems has been investigated. It is concluded while comparing the experimental data with theoretical concepts that beta-naphtol in mitochondria and liposome suspensions binds the radicals according to the "sticking" mechanism, while 5-oxitriptamine reduces hydroperoxides.

摘要

从理论上考虑了抗氧化剂影响含亚铁离子的脂质体系中化学发光不同发展阶段的不同作用机制。对β-萘酚和5-羟色胺(在其他体系中的作用机制已得到研究的抗氧化剂)进行了实验研究。在将实验数据与理论概念进行比较时得出结论:在线粒体和脂质体悬浮液中,β-萘酚根据“黏附”机制结合自由基,而5-羟色胺则还原氢过氧化物。

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