Tiunova A, Anokhin K V, Schachner M, Rose S P
Biology Department, Open University, Milton Keynes, UK.
Neuroreport. 1998 May 11;9(7):1645-8. doi: 10.1097/00001756-199805110-00070.
The L1/NgCAM cell adhesion molecule is involved in neurite outgrowth, axonal fasciculation and cell migration in the nervous system. We studied the effects of antibodies against L1 injected intracranially at various times before and after training 2-day-old chicks in a visual categorization task. Memory retention was tested 24 h post-training. Anti-L1 antibodies impaired task retention only when administered in three restricted time windows: immediately before training, at about 5.5 h after training and from 15 to 18 h after training. No amnesia was produced by injections before, between or after these sensitive periods (from -1 to +21 h relative to training). These results indicate that there are multiple post-training periods during which L1 is involved in the formation of long-term memory.
L1/NgCAM细胞黏附分子参与神经系统中的神经突生长、轴突成束和细胞迁移。我们研究了在对2日龄雏鸡进行视觉分类任务训练之前和之后的不同时间颅内注射抗L1抗体的效果。在训练后24小时测试记忆保持情况。抗L1抗体仅在三个受限的时间窗口给药时会损害任务保持：训练前即刻、训练后约5.5小时以及训练后15至18小时。在这些敏感期之前、之间或之后注射（相对于训练时间从-1至+21小时）均未产生失忆现象。这些结果表明，在训练后的多个时期中，L1参与了长期记忆的形成。
