Navarro M A, Nolla J M, Machuca M I, González A, Mateo L, Bonnin R M, Roig-Escofet D
Biochemistry Department, Ciutat Sanitària i Universitària de Bellvitge, Barcelona, Spain.
J Rheumatol. 1998 Jun;25(6):1059-62.
To study changes in testosterone concentrations in saliva and total testosterone, free testosterone, and sex hormone binding globulin (SHBG) concentrations in serum in 2 groups of postmenopausal women with rheumatoid arthritis (RA), one group with glucocorticoid treatment and the other without it.
The above mentioned hormonal levels were measured in 20 postmenopausal women with RA undergoing glucocorticoid treatment, in 24 postmenopausal women with RA without treatment, and in 36 postmenopausal women without RA.
We observed significantly lower levels of total testosterone in serum, SHBG in serum, testosterone in saliva, and the free testosterone index in the group of patients with RA undergoing glucocorticoid treatment compared to the group without treatment. We did not observe changes in free testosterone concentrations in serum of the groups studied, which is believed due to its lower specificity.
Testosterone in saliva is a useful indicator for monitoring androgenic status in women with RA.
研究两组绝经后类风湿关节炎（RA）女性的唾液睾酮浓度以及血清总睾酮、游离睾酮和性激素结合球蛋白（SHBG）浓度的变化，一组接受糖皮质激素治疗，另一组未接受治疗。
对20例接受糖皮质激素治疗的绝经后RA女性、24例未接受治疗的绝经后RA女性以及36例无RA的绝经后女性测量上述激素水平。
我们观察到，与未接受治疗的组相比，接受糖皮质激素治疗的RA患者组血清总睾酮、血清SHBG、唾液睾酮和游离睾酮指数水平显著降低。我们未观察到所研究组血清游离睾酮浓度的变化，这被认为是由于其特异性较低。
唾液睾酮是监测RA女性雄激素状态的有用指标。
