El Ganouni S, Tazi A, Hakkou F
Department of Biology, Faculty of Science and Technology, Settat, Morocco.
Pharmacol Biochem Behav. 1998 Jun;60(2):365-9. doi: 10.1016/s0091-3057(98)00014-8.
In a series of experiments, we investigated the interaction between the calcium channel antagonist, nifedipine, and the 5-HT1A agonist, ipsapirone. In the first experiment, we demonstrated that nifedipine (20 mg/kg), and to a lesser extent nimodipine (20 mg/kg), exerted an anxiolytic-like effect as did diazepam (5 mg/kg) in an experimental paradigm based on water consumption in a novel environment. In the second experiment, nifedipine (1.25, 2.5, and 5 mg/kg), and in the third experiment, ipsapirone (1.5. 3.0, and 6.0 mg/kg), have been found to exert a dose-dependent effect in the same test. Finally, a small and ineffective dose of ipsapirone (1.5 mg/kg) potentiated the anxiolytic-like effect of various doses of nifedipine. The data obtained are discussed in terms of the potential anxiolytic-like action of calcium channel antagonists and in relation to their electrophysiological effects. Moreover, the interaction between ipsapirone and nifedipine is discussed in terms of the possible involvement of central serotonergic systems in the behavioral effects of the calcium channel antagonists.
在一系列实验中，我们研究了钙通道拮抗剂硝苯地平与5-羟色胺1A受体激动剂伊沙匹隆之间的相互作用。在第一个实验中，我们证明，在基于新环境中饮水情况的实验范式中，硝苯地平（20毫克/千克），以及程度稍轻的尼莫地平（20毫克/千克），与地西泮（5毫克/千克）一样，具有抗焦虑样效应。在第二个实验中，硝苯地平（1.25、2.5和5毫克/千克），并且在第三个实验中，伊沙匹隆（1.5、3.0和6.0毫克/千克），在同一测试中呈现出剂量依赖性效应。最后，小剂量且无效的伊沙匹隆（1.5毫克/千克）增强了不同剂量硝苯地平的抗焦虑样效应。就钙通道拮抗剂潜在的抗焦虑样作用及其电生理效应，对所获得的数据进行了讨论。此外，就中枢5-羟色胺能系统可能参与钙通道拮抗剂的行为效应，对伊沙匹隆与硝苯地平之间的相互作用进行了讨论。
