在流感嗜血杆菌高度流行的人群中，与非包膜型流感嗜血杆菌相比，b型流感嗜血杆菌的遗传多样性较低。
Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic.
作者信息
Smith-Vaughan H C, Sriprakash K S, Leach A J, Mathews J D, Kemp D J
机构信息
Menzies School of Health Research, Darwin, Northern Territory, Australia.
出版信息
Infect Immun. 1998 Jul;66(7):3403-9. doi: 10.1128/IAI.66.7.3403-3409.1998.
Abstract
Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide vaccines has dramatically reduced Hib disease worldwide. As in other populations, nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following vaccination, although carriage has not been entirely eliminated. In this study, we describe the genetic characteristics and the carriage dynamics of longitudinal isolates of Hib, characterized by using several typing methods. In addition, carriage rates of nonencapsulated H. influenzae (NCHi) are high, and concurrent colonization with Hib and NCHi is common; we also observed NCHi isolates which were genetically similar to Hib. There is a continuing need to promote Hib immunization and monitor H. influenzae carriage in populations in which the organism is highly endemic, not least because of the possibility of genetic exchange between Hib and NCHi strains in such populations.
摘要
用b型流感嗜血杆菌（Hib）结合多糖疫苗进行免疫接种已在全球范围内显著降低了Hib疾病的发病率。与其他人群一样，接种疫苗后，原住民婴儿鼻咽部Hib携带率显著下降，尽管携带现象尚未完全消除。在本研究中，我们描述了通过几种分型方法鉴定的Hib纵向分离株的遗传特征和携带动态。此外，非包膜流感嗜血杆菌（NCHi）的携带率很高，Hib和NCHi同时定植很常见；我们还观察到与Hib基因相似的NCHi分离株。持续有必要在该微生物高度流行的人群中推广Hib免疫接种并监测流感嗜血杆菌的携带情况，尤其是因为此类人群中Hib和NCHi菌株之间可能发生基因交换。
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