在流感嗜血杆菌高度流行的人群中，与非包膜型流感嗜血杆菌相比，b型流感嗜血杆菌的遗传多样性较低。
Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic.
作者信息
Smith-Vaughan H C, Sriprakash K S, Leach A J, Mathews J D, Kemp D J
机构信息
Menzies School of Health Research, Darwin, Northern Territory, Australia.
出版信息
Infect Immun. 1998 Jul;66(7):3403-9. doi: 10.1128/IAI.66.7.3403-3409.1998.
Abstract
Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide vaccines has dramatically reduced Hib disease worldwide. As in other populations, nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following vaccination, although carriage has not been entirely eliminated. In this study, we describe the genetic characteristics and the carriage dynamics of longitudinal isolates of Hib, characterized by using several typing methods. In addition, carriage rates of nonencapsulated H. influenzae (NCHi) are high, and concurrent colonization with Hib and NCHi is common; we also observed NCHi isolates which were genetically similar to Hib. There is a continuing need to promote Hib immunization and monitor H. influenzae carriage in populations in which the organism is highly endemic, not least because of the possibility of genetic exchange between Hib and NCHi strains in such populations.
摘要
用b型流感嗜血杆菌（Hib）结合多糖疫苗进行免疫接种已在全球范围内显著降低了Hib疾病的发病率。与其他人群一样，接种疫苗后，原住民婴儿鼻咽部Hib携带率显著下降，尽管携带现象尚未完全消除。在本研究中，我们描述了通过几种分型方法鉴定的Hib纵向分离株的遗传特征和携带动态。此外，非包膜流感嗜血杆菌（NCHi）的携带率很高，Hib和NCHi同时定植很常见；我们还观察到与Hib基因相似的NCHi分离株。持续有必要在该微生物高度流行的人群中推广Hib免疫接种并监测流感嗜血杆菌的携带情况，尤其是因为此类人群中Hib和NCHi菌株之间可能发生基因交换。
相似文献
1
Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic.
Infect Immun. 1998 Jul;66(7):3403-9. doi: 10.1128/IAI.66.7.3403-3409.1998.
2
Identification of Haemophilus influenzae clones associated with invasive disease a decade after introduction of H. influenzae serotype b vaccination in Italy.
Clin Vaccine Immunol. 2013 Aug;20(8):1223-9. doi: 10.1128/CVI.00028-13. Epub 2013 Jun 12.
3
Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines.
Pediatr Infect Dis J. 1993 Jul;12(7):589-93. doi: 10.1097/00006454-199307000-00009.
4
Low rate of nasopharyngeal carriage and high rate of ampicillin resistance for Haemophilus influenzae among healthy children younger than 5 years old in northern Taiwan.
J Microbiol Immunol Infect. 2008 Feb;41(1):32-40.
5
Ten years of Hib vaccination in Italy: prevalence of non-encapsulated Haemophilus influenzae among invasive isolates and the possible impact on antibiotic resistance.
Vaccine. 2011 May 17;29(22):3857-62. doi: 10.1016/j.vaccine.2011.03.059. Epub 2011 Apr 1.
6
Carriage of Haemophilus influenzae in the oropharynx of young children and molecular epidemiology of the isolates after fifteen years of H. influenzae type b vaccination in Italy.
Vaccine. 2015 Nov 17;33(46):6227-34. doi: 10.1016/j.vaccine.2015.09.082. Epub 2015 Oct 9.
7
Widespread of non-typeable Haemophilus influenzae with high genetic diversity after two decades use of Hib vaccine in China.
J Clin Lab Anal. 2020 Apr;34(4):e23145. doi: 10.1002/jcla.23145. Epub 2019 Dec 17.
8
A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan.
Vaccine. 2018 Sep 11;36(38):5678-5684. doi: 10.1016/j.vaccine.2018.08.029. Epub 2018 Aug 16.
9
Carriage of Haemophilus influenzae among Brazilian children attending day care centers in the era of widespread Hib vaccination.
Vaccine. 2011 Feb 4;29(7):1438-42. doi: 10.1016/j.vaccine.2010.12.045. Epub 2011 Jan 1.
10
Increase in genetic diversity of Haemophilus influenzae serotype b (Hib) strains after introduction of Hib vaccination in The Netherlands.
J Clin Microbiol. 2005 Jun;43(6):2741-9. doi: 10.1128/JCM.43.6.2741-2749.2005.
引用本文的文献
1
Carriage among Healthy Children in Portugal, 2015-2019.
Microorganisms. 2022 Oct 4;10(10):1964. doi: 10.3390/microorganisms10101964.
2
Identification of Haemophilus influenzae clones associated with invasive disease a decade after introduction of H. influenzae serotype b vaccination in Italy.
Clin Vaccine Immunol. 2013 Aug;20(8):1223-9. doi: 10.1128/CVI.00028-13. Epub 2013 Jun 12.
3
Pharyngeal colonization dynamics of Haemophilus influenzae and Haemophilus haemolyticus in healthy adult carriers.
J Clin Microbiol. 2007 Oct;45(10):3207-17. doi: 10.1128/JCM.00492-07. Epub 2007 Aug 8.
4
Antimicrobial resistance in Haemophilus influenzae.
Clin Microbiol Rev. 2007 Apr;20(2):368-89. doi: 10.1128/CMR.00040-06.
5
Conservation and diversity of HMW1 and HMW2 adhesin binding domains among invasive nontypeable Haemophilus influenzae isolates.
Infect Immun. 2006 Feb;74(2):1161-70. doi: 10.1128/IAI.74.2.1161-1170.2006.
6
Haemophilus influenzae: genetic variability and natural selection to identify virulence factors.
Infect Immun. 2004 May;72(5):2457-61. doi: 10.1128/IAI.72.5.2457-2461.2004.
7
High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae.
Infect Genet Evol. 2003 May;3(1):57-66. doi: 10.1016/s1567-1348(02)00152-1.
8
Identification of the lipooligosaccharide biosynthesis gene lic2B as a putative virulence factor in strains of nontypeable Haemophilus influenzae that cause otitis media.
Infect Immun. 2002 Jul;70(7):3551-6. doi: 10.1128/IAI.70.7.3551-3556.2002.
9
Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review.
Clin Microbiol Rev. 2001 Apr;14(2):336-63. doi: 10.1128/CMR.14.2.336-363.2001.
10
Characterization of non-type B Haemophilus influenzae strains isolated from patients with invasive disease. The HI Study Group.
J Clin Microbiol. 2000 Dec;38(12):4649-52. doi: 10.1128/JCM.38.12.4649-4652.2000.
本文引用的文献
1
Nonencapsulated Haemophilus influenzae in Aboriginal infants with otitis media: prolonged carriage of P2 porin variants and evidence for horizontal P2 gene transfer.
Infect Immun. 1997 Apr;65(4):1468-74. doi: 10.1128/iai.65.4.1468-1474.1997.
2
Molecular characteristics of Haemophilus influenzae causing invasive disease during the period of vaccination in Switzerland: analysis of strains isolated between 1986 and 1993.
J Clin Microbiol. 1996 Mar;34(3):560-3. doi: 10.1128/jcm.34.3.560-563.1996.
3
Immune selection for antigenic drift of major outer membrane protein P2 of Haemophilus influenzae during persistence in subcutaneous tissue cages in rabbits.
Infect Immun. 1996 Mar;64(3):980-6. doi: 10.1128/iai.64.3.980-986.1996.
4
Carriage of multiple ribotypes of non-encapsulated Haemophilus influenzae in aboriginal infants with otitis media.
Epidemiol Infect. 1996 Apr;116(2):177-83. doi: 10.1017/s0950268800052419.
5
An ancestral mutation enhancing the fitness and increasing the virulence of Haemophilus influenzae type b.
J Infect Dis. 1993 Jul;168(1):172-6. doi: 10.1093/infdis/168.1.172.
6
Comparison of phage typing and DNA fingerprinting by polymerase chain reaction for discrimination of methicillin-resistant Staphylococcus aureus strains.
J Clin Microbiol. 1993 Apr;31(4):798-803. doi: 10.1128/jcm.31.4.798-803.1993.
7
Genes involved in Haemophilus influenzae type b capsule expression are frequently amplified.
J Infect Dis. 1993 Feb;167(2):356-64. doi: 10.1093/infdis/167.2.356.
8
Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates.
Infect Immun. 1994 Jun;62(6):2639-43. doi: 10.1128/iai.62.6.2639-2643.1994.
9
PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2216-20. doi: 10.1073/pnas.91.6.2216.
10
Evidence for capsule gene sequences among pharyngeal isolates of nontypeable Haemophilus influenzae.
J Infect Dis. 1994 Feb;169(2):337-42. doi: 10.1093/infdis/169.2.337.
Zotero 插件