大肠杆菌不耐热肠毒素对II类主要组织相容性复合体抗原加工的抑制作用需要具有酶活性的A亚基。
Inhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile enterotoxin requires an enzymatically active A subunit.
作者信息
Matousek M P, Nedrud J G, Cieplak W, Harding C V
机构信息
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
Infect Immun. 1998 Jul;66(7):3480-4. doi: 10.1128/IAI.66.7.3480-3484.1998.
Abstract
Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT) were found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex complexes. Inhibition of antigen processing correlated with A subunit ADP-ribosyltransferase activity.
摘要
已发现大肠杆菌不耐热肠毒素（LT）和霍乱毒素（CT）可抑制细胞内抗原加工。具有减弱的ADP-核糖基转移酶活性的突变型LT、CT B或LT B亚基不会抑制加工过程，这些亚基可增强预先存在的细胞表面肽 - Ⅱ类主要组织相容性复合体复合物的呈递。抗原加工的抑制与A亚基的ADP-核糖基转移酶活性相关。
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