Scott C D, Hancher C W
Biotechnol Bioeng. 1976 Oct;18(10):1393-1403. doi: 10.1002/bit.260181006.
Reactor systems based on tapered fluidized beds are being developed for aqueous bioprocesses in which adhering microorganisms or immobilized active biological fractions are used. The use of a fluidized bed prevents biomass buildup, accommodates particulates in the feed stream, is compatible with gas sparging, and allows easy removal or addition of the active materials. The tapered reactor tends to stabilize the fluidized bed, thus allowing a much wider range of operating conditions. Preliminary experimental results and an empirical mathematical model of the tapered bed indicate that bed stability is associated with a decreasing velocity and void-fraction profile up the bed and the pressure drop across the bed decreases with increasing flow rates. The tapered fluidized bed bioreactor is being evaluated for use in the enzymatic production of hydrogen, microbiological denitrification, and microbiological degradation of coal conversion aqueous waste streams. The enzyme catalyzed conversion of lactose to glucose and galactose was used in the evaluation of the reactor concept.
基于锥形流化床的反应器系统正在为水相生物过程而开发，在这些过程中会使用附着的微生物或固定化的活性生物组分。流化床的使用可防止生物质积累，容纳进料流中的颗粒，与气体喷射兼容，并允许轻松去除或添加活性材料。锥形反应器倾向于稳定流化床，从而允许更广泛的操作条件。锥形床的初步实验结果和经验数学模型表明，床层稳定性与沿床层向上速度和空隙率的降低有关，并且床层压降随流速增加而降低。正在评估锥形流化床生物反应器在酶法生产氢气、微生物反硝化以及煤转化水相废物流的微生物降解中的应用。在反应器概念评估中使用了酶催化乳糖转化为葡萄糖和半乳糖的反应。
