Vitális Z, Altorjay I, Udvardy M
Debreceni Orvostudományi Egyetem, II. sz. Belklinika.
Orv Hetil. 1998 May 24;139(21):1289-94.
Several theories have already been postulated in connection with the pathogenesis of inflammatory bowel diseases, yet none of them has been approved. Recently increasing attention has been payed to different cytokines, playing central role in the development of inflammatory processes. In the intestinal mucosa of patients suffering from inflammatory bowel diseases increasing amounts of interleukin-1 (IL-1), tumor necrosis factor (TNF) and platelet activating factor (PAF) could be measured. On the other hand, antiinflammatory cytokines seem to be ineffective, or being present in insufficient amount (IL-4 and IL-10 respectively). It is therefore probable, that altered ratios of cytokines, or pathologic regulation of their production lead to progression of inflammation in IBD. Influence of cytokine production may open new therapeutic approach, e.g. IL-10 enema proved to be effective in the treatment of some cases of steroid-resistant ulcerative colitis, while intravenous administration was useful in Crohn's disease. A brief, comprehensive review of our present knowledge about cytokines in IBD is given.
关于炎症性肠病的发病机制，已经提出了几种理论，但均未得到证实。最近，人们越来越关注在炎症过程发展中起核心作用的不同细胞因子。在患有炎症性肠病的患者的肠黏膜中，可以检测到白细胞介素-1（IL-1）、肿瘤坏死因子（TNF）和血小板活化因子（PAF）的含量增加。另一方面，抗炎细胞因子似乎无效，或者含量不足（分别为IL-4和IL-10）。因此，细胞因子比例的改变或其产生的病理调节可能导致炎症性肠病中炎症的进展。细胞因子产生的影响可能开辟新的治疗方法，例如，IL-10灌肠剂被证明对治疗某些类固醇抵抗性溃疡性结肠炎病例有效，而静脉注射对克罗恩病有用。本文对我们目前关于炎症性肠病中细胞因子的知识进行了简要而全面的综述。
