Gillam P M, Prichard B N
Postgrad Med J. 1976;52 Suppl 4:70-5.
Following the observation that pronethalol lowered the blood pressure a similar effect was demonstrated with propranolol. Over a period of years propranolol was demonstrated to produce a fall in blood pressure comparable with other potent drugs with the advantage of good control of the supine blood pressure and with the absence of postural and exercise hypotension. These observations were slow to be accepted, as besides a novel mode of action, most attempts to repeat the work failed to pay enough attention to adequate dosage.
在观察到丙萘洛尔能降低血压后，普萘洛尔也显示出类似的效果。经过数年时间，已证明普萘洛尔能使血压下降，其效果与其他强效药物相当，优势在于能很好地控制仰卧位血压，且不存在体位性和运动性低血压。这些观察结果起初难以被接受，因为除了其新颖的作用方式外，大多数重复该研究的尝试都没有充分注意到足够的剂量。
