Butler R, Holland P, Devitt H, Hiley E, Roberts G, Redfern E
Department of Clinical Psychology, Leeds CMH Services Trust, UK.
Br J Urol. 1998 May;81 Suppl 3:29-36. doi: 10.1046/j.1464-410x.1998.00004.x.
To determine the factors that predict the effectiveness of desmopressin in the treatment of childhood nocturnal enuresis.
Sixty-six children with monosymptomatic nocturnal enuresis were treated with intranasal or oral desmopressin for a 4-week period. starting with a standard dose of 20 microg (0.2 mg oral) and increasing after 2 weeks where no progress was apparent to 40 microg (0.4 mg oral). Before treatment a range of variables (demographic, situational, enuretic history, physiological, parental attitude and child) were recorded. Three parameters of success acted as dependent variables, with stepwise linear regression models used to determine pretreatment predictors of success with desmopressin.
Each outcome variable produced a very similar model of predictors. Success, as assessed by the most dry nights over a 14-night period, was associated with less severe enuresis before treatment, a parental belief that the child's enuresis was unstable and higher birthweight.
From the analysis, a model of arginine vasopressin release is proposed and the clinical implications of the findings addressed.
确定预测去氨加压素治疗儿童夜间遗尿症疗效的因素。
66名单症状性夜间遗尿症儿童接受鼻内或口服去氨加压素治疗4周。起始标准剂量为20微克（口服0.2毫克），2周后若未见明显进展则增至40微克（口服0.4毫克）。治疗前记录一系列变量（人口统计学、情境、遗尿病史、生理、父母态度及儿童情况）。成功的三个参数作为因变量，采用逐步线性回归模型确定去氨加压素治疗成功的治疗前预测因素。
每个结果变量产生的预测模型非常相似。以14晚期间最干燥的夜晚数评估的成功与治疗前遗尿症较轻、父母认为孩子的遗尿症不稳定以及出生体重较高有关。
通过分析，提出了精氨酸加压素释放模型，并探讨了研究结果的临床意义。
