Zawisza E, Lipiec A, Rapiejko P
Poradni Alergologicznej Przychodni Przyszpitalnej CSK AM w Warszawie.
Pol Merkur Lekarski. 1998 Feb;4(20):66-8.
The aim of the study was to assess efficacy and safety of 5 mg loratadine/120 mg pseudoephedrine combination drug in patients with seasonal allergic rhinitis. 30 patients allergic to grass pollen were treated with the new drug (Clarinase) twice a day in 15-day study during grass pollen seasonal. Nasal an non-nasal symptoms were evaluated for efficacy. Loratadine/pseudoephedrine combination effected a significant decrease in total symptoms score as well as individual evaluated symptoms score: nasal stuffiness, itching and discharge, sneezing, eye itching, tearing and redness of the eyes. The treatments was well tolerated. No serious side effects were noticed. The incidence of mild sedation, dry mouth, insomnia and nervousness was only 3 to 7 percent. 5 mg loratadine plus 120 mg pseudoephedrine was safe and effective in relieving the symptoms of allergic rhinitis.
本研究的目的是评估5毫克氯雷他定/120毫克伪麻黄碱复方药物治疗季节性变应性鼻炎患者的疗效和安全性。30名对草花粉过敏的患者在草花粉季节进行了为期15天的研究，每天两次服用新药（克敏能）。评估鼻和非鼻症状以确定疗效。氯雷他定/伪麻黄碱复方显著降低了总症状评分以及各个评估症状的评分：鼻阻塞、瘙痒、流涕、打喷嚏、眼痒、流泪和眼红。该治疗耐受性良好。未观察到严重副作用。轻度镇静、口干、失眠和紧张的发生率仅为3%至7%。5毫克氯雷他定加120毫克伪麻黄碱在缓解变应性鼻炎症状方面安全有效。
