子宫颈癌中的分子事件
Molecular events in uterine cervical cancer.
作者信息
Southern S A, Herrington C S
机构信息
Department of Pathology, University of Liverpool, Royal Liverpool University Hospital.
出版信息
Sex Transm Infect. 1998 Apr;74(2):101-9. doi: 10.1136/sti.74.2.101.
OBJECTIVE
To review the literature regarding the molecular events which occur in the development of uterine cervical cancer, with particular reference to human papillomavirus (HPV) infection.
METHODOLOGY
Bibliographic searches of Medline and the ISI citation databases using appropriate keywords, including the following: papillomavirus, cervix, pathology, cyclin, chromosome, heterozygosity, telomerase, smoking, hormones, HLA, immune response, HIV, HSV, EBV.
CONCLUSIONS
It has become clear that most cervical neoplasia, whether intraepithelial or invasive, is attributable in part to HPV infection. However, HPV infection alone is not sufficient, and, in a small proportion of cases, may not be necessary for malignant transformation. There is increasing evidence that HPV gene products interfere with cell cycle control leading to secondary accumulation of small and large scale genetic abnormalities. This may explain the association of viral persistence with lesion progression but, in many patients, secondary factors, such as smoking and immune response, are clearly important. However, the mechanisms involved in the interaction between HPV and host factors are poorly understood.
目的
回顾有关子宫颈癌发生过程中分子事件的文献，特别提及人乳头瘤病毒（HPV）感染。
方法
使用适当关键词对医学索引数据库（Medline）和科学信息研究所（ISI）引文数据库进行文献检索，关键词包括：乳头瘤病毒、子宫颈、病理学、细胞周期蛋白、染色体、杂合性、端粒酶、吸烟、激素、人类白细胞抗原（HLA）、免疫反应、人类免疫缺陷病毒（HIV）、单纯疱疹病毒（HSV）、EB病毒（EBV）。
结论
现已明确，大多数子宫颈肿瘤，无论是上皮内肿瘤还是浸润性肿瘤，部分归因于HPV感染。然而，仅HPV感染并不足够，在一小部分病例中，其对于恶性转化可能也不是必需的。越来越多的证据表明，HPV基因产物干扰细胞周期调控，导致小规模和大规模基因异常的继发性积累。这可能解释了病毒持续感染与病变进展之间的关联，但在许多患者中，诸如吸烟和免疫反应等次要因素显然也很重要。然而，HPV与宿主因素之间相互作用的机制仍知之甚少。
Zotero 插件