Walboomers J M, Meijer C J
J Pathol. 1997 Mar;181(3):253-4. doi: 10.1002/(SICI)1096-9896(199703)181:3<253::AID-PATH755>3.0.CO;2-0.
Based on improvements in HPV detection technology, it appears that an almost 100% HPV association is reached for cervical cancer, as demonstrated in an accompanying paper in this issue of the Journal. Factors which may explain the rare cases in which no HPV DNA is detectable include: improper sampling; disruption of HPV by integration events; the existence of still unidentified HPVs; sensitivity of the method; and the mechanism of transformation. Finally, epidemiological studies identifying HPV independent risk factors are necessary to answer the question of whether HPV independent pathways exist for cervical carcinogenesis.
基于人乳头瘤病毒（HPV）检测技术的改进，本期《杂志》的一篇相关论文表明，宫颈癌与人乳头瘤病毒的关联度几乎达到了100%。对于罕见的无法检测到HPV DNA的病例，可能的解释因素包括：采样不当；整合事件导致HPV被破坏；仍未识别的HPV的存在；检测方法的灵敏度；以及转化机制。最后，需要开展确定HPV独立风险因素的流行病学研究，以解答宫颈癌发生过程中是否存在HPV独立途径这一问题。
