Ogilvie G K
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Ft. Collins 80523, USA.
Clin Tech Small Anim Pract. 1998 Feb;13(1):22-32. doi: 10.1016/S1096-2867(98)80023-6.
Surgery is the mainstay of cancer therapy, yet there is mounting information demonstrating that chemotherapy is effective for the treatment of a wide variety of malignancies in dogs, cats and horses. Chemotherapy is not only being used to delay or eliminate metastatic disease, but also to enhance the local control of malignancies. New drugs and innovative combinations of chemotherapeutic agents are being evaluated at an ever increasing rate. Anticancer drugs are being delivered safer and more effectively because patients are being treated in new ways such as intralesionally or within body cavities. These agents are also being scheduled in more effective ways such as prior to, during, or after surgery. Techniques are being developed for drugs to be inhaled to reduce metastatic pulmonary disease. The purpose of this article is to review the general principals of cancer chemotherapy, the various toxicoses associated with these drugs, as well as examples of how chemotherapy has been used in combination with surgery.
手术是癌症治疗的主要手段，但越来越多的信息表明，化疗对治疗犬、猫和马的多种恶性肿瘤有效。化疗不仅用于延缓或消除转移性疾病，还用于加强对恶性肿瘤的局部控制。新型药物和化疗药物的创新组合正在以越来越快的速度进行评估。抗癌药物的给药方式更安全、更有效，因为患者正在接受新的治疗方式，如瘤内注射或体腔内给药。这些药物的给药时间安排也更有效，如在手术前、手术期间或手术后给药。正在开发药物吸入技术以减少转移性肺部疾病。本文的目的是回顾癌症化疗的一般原则、与这些药物相关的各种毒性反应，以及化疗与手术联合应用的实例。
