Pharmacogenetics of cancer therapy: getting personal.
作者信息
Krynetski E Y, Evans W E
机构信息
St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Am J Hum Genet. 1998 Jul;63(1):11-6. doi: 10.1086/301941.
Abstract
摘要
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Am J Hum Genet. 1998 Jul;63(1):6-10. doi: 10.1086/301942.
2
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.伊立替康（CPT-11）代谢的遗传易感性。尿苷二磷酸葡萄糖醛酸基转移酶同工型1A1在人肝微粒体中其活性代谢物（SN-38）葡萄糖醛酸化中的作用。
J Clin Invest. 1998 Feb 15;101(4):847-54. doi: 10.1172/JCI915.
3
Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.
Clin Pharmacol Ther. 1997 Jul;62(1):60-73. doi: 10.1016/S0009-9236(97)90152-1.
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Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.多态性表达的CYP2C19和野生型CYP2C9-ILE359等位基因作为环磷酰胺和异环磷酰胺活化的低Km催化剂的鉴定。
Pharmacogenetics. 1997 Jun;7(3):211-21. doi: 10.1097/00008571-199706000-00006.
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Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.人类中由突变等位基因（TPMT*3A、TPMT*2）编码的硫嘌呤S-甲基转移酶（TPMT）的蛋白水解增强：TPMT活性遗传多态性的机制
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6444-9. doi: 10.1073/pnas.94.12.6444.
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Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.硫嘌呤S-甲基转移酶缺乏症的分子诊断：硫唑嘌呤和巯嘌呤不耐受的遗传基础。
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Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?药物代谢酶中的多态性：其临床意义是什么，以及它们为何存在？
Am J Hum Genet. 1997 Feb;60(2):265-71.
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Busulfan conjugation by glutathione S-transferases alpha, mu, and pi.谷胱甘肽S-转移酶α、μ和π介导的白消安结合反应
Drug Metab Dispos. 1996 Sep;24(9):1015-9.
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Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.硫嘌呤 S - 甲基转移酶的基因多态性：临床重要性及分子机制
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