神经营养因子-4的局部突触作用。
Localized synaptic actions of neurotrophin-4.
作者信息
Wang X, Berninger B, Poo M
机构信息
Department of Biology, University of California at San Diego, La Jolla, California 92093-0357, USA.
出版信息
J Neurosci. 1998 Jul 1;18(13):4985-92. doi: 10.1523/JNEUROSCI.18-13-04985.1998.
Abstract
Neurotrophins secreted by the postsynaptic target cell may participate in activity-dependent synaptic modification during development and in the mature brain. A fundamental question of how neurotrophins can sculpt synaptic connections is whether neurotrophin-induced synaptic changes are spatially restricted to the site of neurotrophin secretion or whether they can spread to neighboring synapses. Using a model system of nerve-muscle coculture in which neurotrophin-4 (NT-4) is overexpressed in a subpopulation of postsynaptic myocytes, we demonstrated that presynaptic potentiation is restricted to synapses on myocytes overexpressing NT-4 without affecting nearby synapses formed by the same neuron on control myocytes. Likewise, postsynaptic modulation of acetylcholine channels by secreted NT-4 is spatially restricted to <60 micron from the site of NT-4 secretion. Therefore, activity-dependent secretion of neurotrophins can result in highly localized modification of neuronal connections.
摘要
由突触后靶细胞分泌的神经营养因子可能在发育过程以及成熟大脑中参与依赖活动的突触修饰。神经营养因子如何塑造突触连接这一基本问题在于，神经营养因子诱导的突触变化在空间上是局限于神经营养因子分泌位点，还是能够扩散到相邻突触。利用神经肌肉共培养模型系统，其中神经营养因子4（NT-4）在突触后肌细胞亚群中过表达，我们证明突触前增强局限于过表达NT-4的肌细胞上的突触，而不影响同一神经元在对照肌细胞上形成的附近突触。同样，分泌的NT-4对乙酰胆碱通道的突触后调节在空间上局限于距NT-4分泌位点<60微米的范围内。因此，神经营养因子的依赖活动分泌可导致神经元连接的高度局部修饰。
相似文献
1
Localized synaptic actions of neurotrophin-4.神经营养因子-4的局部突触作用。
J Neurosci. 1998 Jul 1;18(13):4985-92. doi: 10.1523/JNEUROSCI.18-13-04985.1998.
2
Neurotrophins regulate agrin-induced postsynaptic differentiation.神经营养因子调节聚集蛋白诱导的突触后分化。
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1112-7. doi: 10.1073/pnas.96.3.1112.
3
Potentiation of developing synapses by postsynaptic release of neurotrophin-4.神经营养因子-4的突触后释放对发育中突触的增强作用。
Neuron. 1997 Oct;19(4):825-35. doi: 10.1016/s0896-6273(00)80964-2.
4
Glia cell line-derived neurotrophic factor regulates the distribution of acetylcholine receptors in mouse primary skeletal muscle cells.胶质细胞系源性神经营养因子调节小鼠原代骨骼肌细胞中乙酰胆碱受体的分布。
Neuroscience. 2004;128(3):497-509. doi: 10.1016/j.neuroscience.2004.06.067.
5
The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.神经肌肉接头：神经/肌肉界面处突触调节蛋白的选择性重塑。
Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
6
Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS.神经营养因子对哺乳动物中枢神经系统中谷氨酸能突触传递的依赖性调节。
Gen Pharmacol. 1998 Nov;31(5):667-74. doi: 10.1016/s0306-3623(98)00190-6.
7
Reciprocal regulation of ciliary neurotrophic factor receptors and acetylcholine receptors during synaptogenesis in embryonic chick atria.胚胎期鸡心房突触形成过程中睫状神经营养因子受体与乙酰胆碱受体的相互调节
J Neurosci. 1998 Sep 15;18(18):7372-80. doi: 10.1523/JNEUROSCI.18-18-07372.1998.
8
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.神经营养因子对非洲爪蟾细胞培养中发育的运动神经元量子分泌的调节。
J Physiol. 1997 Aug 15;503 ( Pt 1)(Pt 1):129-39. doi: 10.1111/j.1469-7793.1997.129bi.x.
9
Target-dependent regulation of acetylcholine secretion at developing motoneurons in Xenopus cell cultures.非洲爪蟾细胞培养中发育性运动神经元乙酰胆碱分泌的靶依赖性调节。
J Physiol. 1999 Jun 15;517 ( Pt 3)(Pt 3):721-30. doi: 10.1111/j.1469-7793.1999.0721s.x.
10
Regulation of quantal secretion from developing motoneurons by postsynaptic activity-dependent release of NT-3.通过突触后活动依赖性释放NT-3对发育中运动神经元的量子分泌进行调节。
J Neurosci. 1997 Apr 1;17(7):2459-68. doi: 10.1523/JNEUROSCI.17-07-02459.1997.
引用本文的文献
1
The role of the TrkB-T1 receptor in the neurotrophin-4/5 antagonism of brain-derived neurotrophic factor on corticostriatal synaptic transmission.TrkB-T1受体在脑源性神经营养因子对皮质纹状体突触传递的神经营养因子-4/5拮抗作用中的作用。
Neural Regen Res. 2020 Nov;15(11):1973-1976. doi: 10.4103/1673-5374.282224.
2
NT-4/5 antagonizes the BDNF modulation of corticostriatal transmission: Role of the TrkB.T1 receptor.NT-4/5 拮抗 BDNF 对皮质纹状体传递的调制：TrkB.T1 受体的作用。
CNS Neurosci Ther. 2019 May;25(5):621-631. doi: 10.1111/cns.13091. Epub 2019 Jan 21.
3
Mechanisms of BDNF regulation in asthmatic airway smooth muscle.哮喘气道平滑肌中脑源性神经营养因子的调控机制
Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L270-9. doi: 10.1152/ajplung.00414.2015. Epub 2016 Jun 17.
4
7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.7,8-二羟基黄酮可改善肌萎缩侧索硬化症模型小鼠的运动性能并增强运动神经元的存活。
Neurosci Lett. 2014 Apr 30;566:286-91. doi: 10.1016/j.neulet.2014.02.058. Epub 2014 Mar 15.
5
TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle.瞬时受体电位通道3调节人脑气道平滑肌中脑源性神经营养因子的释放。
Biochim Biophys Acta. 2013 Dec;1833(12):2953-2960. doi: 10.1016/j.bbamcr.2013.07.019. Epub 2013 Jul 27.
6
Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle.脑源性神经营养因子增强人呼吸道平滑肌的钙调节机制。
PLoS One. 2012;7(8):e44343. doi: 10.1371/journal.pone.0044343. Epub 2012 Aug 29.
7
The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission.新型 TrkB 受体激动剂 7,8-二羟基黄酮增强神经肌肉传递。
Muscle Nerve. 2012 Feb;45(2):274-6. doi: 10.1002/mus.22295.
8
Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle.衰老骨骼肌中兴奋-收缩偶联蛋白的表达与调控
Curr Aging Sci. 2011 Dec;4(3):248-59. doi: 10.2174/1874609811104030248.
9
BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.健康对照受试者中脑源性神经营养因子多态性rs6265与海马结构及记忆表现
Psychiatry Res. 2010 Jul 30;178(2):425-9. doi: 10.1016/j.psychres.2009.09.008. Epub 2010 May 20.
10
Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance.海马神经元循环利用脑源性神经营因子以进行活动依赖型分泌和长时程增强维持。
EMBO J. 2006 Sep 20;25(18):4372-80. doi: 10.1038/sj.emboj.7601303. Epub 2006 Sep 7.
本文引用的文献
1
Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.海兔感觉运动突触特异性的长期易化：局部蛋白质合成在记忆存储中的作用。
Cell. 1997 Dec 26;91(7):927-38. doi: 10.1016/s0092-8674(00)80484-5.
2
Potentiation of developing synapses by postsynaptic release of neurotrophin-4.神经营养因子-4的突触后释放对发育中突触的增强作用。
Neuron. 1997 Oct;19(4):825-35. doi: 10.1016/s0896-6273(00)80964-2.
3
Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation.神经营养因子与时间：TrkB信号在海马体长期增强效应中的不同作用
Neuron. 1997 Sep;19(3):653-64. doi: 10.1016/s0896-6273(00)80378-5.
4
Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns.脑源性神经营养因子（TrkB）内源性配体的阻断会抑制眼优势柱的形成。
Neuron. 1997 Jul;19(1):63-76. doi: 10.1016/s0896-6273(00)80348-7.
5
Propagation of activity-dependent synaptic depression in simple neural networks.简单神经网络中活动依赖型突触抑制的传播
Nature. 1997 Jul 31;388(6641):439-48. doi: 10.1038/41267.
6
Synapse specificity of long-term potentiation breaks down at short distances.长时程增强的突触特异性在短距离内会失效。
Nature. 1997 Jul 17;388(6639):279-84. doi: 10.1038/40870.
7
Synapse specificity and long-term information storage.突触特异性与长期信息存储。
Neuron. 1997 Mar;18(3):339-42. doi: 10.1016/s0896-6273(00)81234-9.
8
Activity-dependent expression of NT-3 in muscle cells in culture: implications in the development of neuromuscular junctions.培养的肌肉细胞中神经营养因子-3（NT-3）的活性依赖性表达：对神经肌肉接头发育的影响
J Neurosci. 1997 May 1;17(9):2947-58. doi: 10.1523/JNEUROSCI.17-09-02947.1997.
9
Role of transforming growth factor-beta in long-term synaptic facilitation in Aplysia.转化生长因子-β在海兔长期突触易化中的作用。
Science. 1997 Feb 28;275(5304):1318-20. doi: 10.1126/science.275.5304.1318.
10
Synaptic tagging and long-term potentiation.突触标记与长时程增强
Nature. 1997 Feb 6;385(6616):533-6. doi: 10.1038/385533a0.
Zotero 插件