Tola M A, Yugueros M I, Fernández-Buey N, Marco J, Gutiérrez-García J M, Gómez-Nieto J, Fernández-Herranz R
Servicio de Neurología, Hospital Universitario de Valladolid, España.
Rev Neurol. 1998 May;26(153):728-34.
Apart from impairment there is hardly any other assessment of the repercussions of multiple sclerosis (MS) in population studies.
To analyze the functional state of en epidemiological series of patients in the Valladolid health district.
A descriptive transversal study of a geographically defined population base. During a period of three months and complementing a prevalence study, were assessed, by means of the Minimal Record of Disability, impairment, disability and handicap in a series of 51 patients (33 women and 18 men) with clinically defined MS, who lived in the area on 1 March 1997.
There was a primarily progressive evolution in 21.6% of the patients, and secondarily progressive in 11.8%. Average follow-up time was 9.1 years (range 1-41) and average age of onset 27.8 years (range 14.7-51.0). The distribution of scores on the Expanded Disability Status Scale was bimodal (average and interquartile range: 3.0 (1.5-5.0). 80.4% of the patients continued to be ambulatory. 21.5% had frequent urinary incontinence or required a long-term urinary catheter. Less than 20% needed help with day to day activities. 78% of the patients complained of some degree of fatigue, and 51% had difficulties with social relationships. 59.4% of the patients had full-time jobs and 70.6% had no financial problems.
The study shows that the functional state of persons with MS is better than was thought, and that assessment of the consequences of this illness should include disability and handicap profiles.
在人群研究中，除了损伤之外，几乎没有对多发性硬化症（MS）的影响进行其他评估。
分析巴利亚多利德健康区一系列患者的功能状态。
对一个地理定义的人群基础进行描述性横断面研究。在为期三个月的时间里，作为一项患病率研究的补充，通过残疾最小记录，对一系列51例（33名女性和18名男性）临床确诊为MS的患者进行了损伤、残疾和残障评估，这些患者于1997年3月1日居住在该地区。
21.6%的患者呈原发性进行性病程，11.8%呈继发性进行性病程。平均随访时间为9.1年（范围1 - 41年），平均发病年龄为27.8岁（范围14.7 - 51.0岁）。扩展残疾状态量表评分分布呈双峰型（平均值和四分位间距：3.0（1.5 - 5.0））。80.4%的患者仍可行走。21.5%的患者经常尿失禁或需要长期留置导尿管。不到20%的患者在日常生活活动中需要帮助。78%的患者抱怨有某种程度的疲劳，51%的患者在社交关系方面存在困难。59.4%的患者有全职工作，70.6%的患者没有经济问题。
该研究表明，MS患者的功能状态比之前认为的要好，并且对这种疾病后果的评估应包括残疾和残障情况。
