Tola M A, Yugueros M I, Fernández-Buey N, Fernández-Herranz R
Servicio de Neurología, Hospital Universitario de Valladolid, España.
Rev Neurol. 1998 Jun;26(154):930-3.
Fatigue is one of the commonest findings in multiple sclerosis (MS) although it has scarcely been investigated as an independent symptom.
To evaluate the effect of fatigue in a population based series of patients with MS and to analyze its relation to other clinical variables.
A descriptive, transverse study based on a geographically defined population. Fatigue was measured using the Krupp scale in 48 patients with definite clinical MS. We analyzed the relation between the degree of fatigue and sex, age of onset, age at the time of the study, type of evolution, index of progression of disability, duration of illness and degree of impairment according to the Expanded Disability Status Scale (EDSS) and neurological functional systems.
64.6% of the patients had a significant degree of fatigue. Of these, 90% considered fatigue to be one of the three most disabling symptoms of their illness. There was no difference between men and women in their perception of fatigue. The patients with progressive illness, of greater age and those with higher EDSS scores had more fatigue. This aspect was not affected by age of onset, duration of illness nor index of progression.
Fatigue should be evaluated as an independent symptom of MS. Evaluation using specific scales may contribute to better understanding of the physiopathology and investigation of more effective treatment.
疲劳是多发性硬化症（MS）最常见的症状之一，尽管它很少被作为一种独立症状进行研究。
评估基于人群的多发性硬化症患者系列中疲劳的影响，并分析其与其他临床变量的关系。
一项基于地理定义人群的描述性横断面研究。使用克鲁普量表对48例确诊为临床多发性硬化症的患者进行疲劳测量。我们根据扩展残疾状态量表（EDSS）和神经功能系统分析了疲劳程度与性别、发病年龄、研究时年龄、病程类型、残疾进展指数、病程长短以及损伤程度之间的关系。
64.6%的患者有明显程度的疲劳。其中，90%的患者认为疲劳是其疾病最具致残性的三种症状之一。男性和女性对疲劳的感知没有差异。病程呈进展性、年龄较大以及EDSS评分较高的患者疲劳程度更高。这方面不受发病年龄、病程长短或进展指数的影响。
应将疲劳作为多发性硬化症的一种独立症状进行评估。使用特定量表进行评估可能有助于更好地理解其病理生理学，并有助于研究更有效的治疗方法。
