Martin L J, Jones P J, Considine R V, Su W, Boyd N F, Caro J F
Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Canada.
Can J Physiol Pharmacol. 1998 Feb;76(2):237-41.
To investigate whether circulating leptin levels are associated with energy expenditure in healthy humans, doubly labeled water energy measurements and food intake assessment were carried out in 27 women (mean age, 48.6 years; weight, 61.9 kg; body mass index, 23.2). Energy expenditure was determined over 13 days. Food intake was measured by 7-day food records. Leptin was measured by radioimmunoassay. Leptin level was strongly associated with percentage body fat (r = 0.59; p < 0.001), fat mass (r = 0.60; p < 0.001), and body mass index (r = 0.41; p = 0.03), but no correlation was observed with energy expenditure (r = 0.02; p = 0.93). After controlling for percentage body fat, a positive association of leptin level with energy expenditure of marginal significance (p = 0.06) was observed. There were no significant univariate associations of age, physical activity, lean body mass, height, or dietary variables with leptin level. When controlling for body fat, a significant positive correlation was observed for percent energy from carbohydrate and negative correlations with dietary fat and alcohol intake. These findings confirm previous associations between leptin and body fat content and suggest a relationship between serum leptin and energy expenditure level in healthy humans.
为研究在健康人群中循环瘦素水平是否与能量消耗相关，对27名女性（平均年龄48.6岁；体重61.9千克；体重指数23.2）进行了双标水能量测量和食物摄入量评估。在13天内测定能量消耗。通过7天食物记录来测量食物摄入量。采用放射免疫分析法测定瘦素。瘦素水平与体脂百分比（r = 0.59；p < 0.001）、脂肪量（r = 0.60；p < 0.001）和体重指数（r = 0.41；p = 0.03）密切相关，但与能量消耗无相关性（r = 0.02；p = 0.93）。在控制体脂百分比后，观察到瘦素水平与能量消耗呈边缘显著的正相关（p = 0.06）。年龄、身体活动、去脂体重、身高或饮食变量与瘦素水平无显著单变量相关性。在控制体脂后，观察到碳水化合物供能百分比呈显著正相关，而与膳食脂肪和酒精摄入量呈负相关。这些发现证实了先前瘦素与体脂含量之间的关联，并提示健康人群血清瘦素与能量消耗水平之间存在关系。
