Mulligan G, Jacks T
Center for Cancer Research, Howard Hughes Medical Institute, Cambridge, MA, USA.
Trends Genet. 1998 Jun;14(6):223-9. doi: 10.1016/s0168-9525(98)01470-x.
The retinoblastoma tumor suppressor gene (RB1) and its relatives, p107 and p130, encode a family of proteins that share several properties, including the capacity to regulate E2F-dependent transcription and inhibit cell-cycle progression. Although RB1 inactivation is widely implicated in human cancer, the growth regulatory functions of p107 and p130, and the functional relationships within the gene family, are emerging only recently. Here we review studies of RB1 gene family function, with emphasis on in vivo experiments that explore shared and distinct functions within this family.
视网膜母细胞瘤肿瘤抑制基因（RB1）及其相关基因p107和p130编码一类具有多种共同特性的蛋白质，包括调节E2F依赖的转录以及抑制细胞周期进程的能力。尽管RB1失活在人类癌症中广泛存在，但p107和p130的生长调节功能以及该基因家族内的功能关系直到最近才逐渐明晰。在此，我们综述RB1基因家族功能的研究，重点关注探索该家族内共同和独特功能的体内实验。
