Singh B, Balwally A N, Sundaram K, Har-El G, Krgin B
Department of Otolaryngology, State University of New York Health Science Center at Brooklyn, USA.
Ann Otol Rhinol Laryngol. 1998 Jun;107(6):519-24. doi: 10.1177/000348949810700611.
Skepticism has surrounded the existence of branchial cleft carcinoma since the entity was first described in 1882. However, a landmark work of 1950 established four criteria for the diagnosis of branchial cleft carcinoma, the most important criterion being histologic proof of carcinoma arising from a normal cyst epithelium. Of the 43 cases found in an extensive review of the literature, only 7 cases have satisfied all four of the criteria. To this we add 2 patients who had recurrent infections of a cervical cyst as children and later developed carcinoma within these structures. Additionally, we propose a minor modification to the 1950 criteria and a paradigm for diagnosis and management of these lesions.
自1882年首次描述鳃裂癌实体以来，围绕其存在一直存在怀疑态度。然而，1950年的一项具有里程碑意义的研究确立了诊断鳃裂癌的四项标准，其中最重要的标准是癌起源于正常囊肿上皮的组织学证据。在对文献进行广泛回顾中发现的43例病例中，只有7例满足所有四项标准。在此基础上，我们补充了2例儿童时期有颈囊肿反复感染且后来在这些结构内发生癌变的患者。此外，我们对1950年的标准提出了一个小修改以及这些病变的诊断和管理模式。
