Nelson J C
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA.
J Clin Psychiatry. 1998;59 Suppl 5:65-8; discussion 69.
Combinations of antidepressants with both serotonergic and noradrenergic activity may be especially effective and thus useful in treating refractory patients and severely depressed patients. In the current report, studies of combinations of serotonin selective reuptake inhibitors (SSRIs) and noradrenergic tricyclics or of SSRIs and bupropion are reviewed, and practical issues pertaining to their use are discussed.
具有5-羟色胺能和去甲肾上腺素能活性的抗抑郁药联合使用可能特别有效，因此对治疗难治性患者和重度抑郁症患者有用。在本报告中，对5-羟色胺选择性再摄取抑制剂（SSRI）与去甲肾上腺素能三环类药物联合使用或SSRI与安非他酮联合使用的研究进行了综述，并讨论了与它们使用相关的实际问题。
