接受辅助化疗的原发性乳腺癌患者的血浆胰岛素样生长因子
Plasma insulin-like growth factor in primary breast cancer patients treated with adjuvant chemotherapy.
作者信息
Peyrat J P, Révillion F, Bonneterre J
机构信息
Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France.
出版信息
Br J Cancer. 1998 May;77(10):1669-71. doi: 10.1038/bjc.1998.274.
Abstract
Insulin-like growth factor 1 (IGF-1) plasma level was assayed in 60 breast cancer patients undergoing six courses of adjuvant chemotherapy. The only observed variation was a slight decrease (10%) in IGF-1 concentrations, assayed before treatment, between the first and the second courses of chemotherapy. During chemotherapy courses, there were no statistically significant variations in IGF-1. These results suggest that chemotherapy, unlike the specific hormonal treatments tamoxifen and somatostatin, certainly does not act via a decrease in plasma IGF-1.
摘要
对60例接受六个疗程辅助化疗的乳腺癌患者测定了血浆胰岛素样生长因子1（IGF-1）水平。唯一观察到的变化是在化疗的第一疗程和第二疗程之间，治疗前测定的IGF-1浓度略有下降（10%）。在化疗疗程期间，IGF-1没有统计学上的显著变化。这些结果表明，与他莫昔芬和生长抑素等特定激素治疗不同，化疗肯定不是通过降低血浆IGF-1起作用的。
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