Hricik D E
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Transplant Proc. 1998 Jun;30(4):1380-2. doi: 10.1016/s0041-1345(98)00282-6.
Steroid-free immunosuppression remains an attractive goal in an era in which the transplant community should be promoting long-term allograft survival by reducing cardiovascular risk and maximizing long-term patient survival. In the cyclosporine era, the risks of steroid withdrawal outweighed the benefits of steroid withdrawal in a substantial minority of patients. A number of new immunosuppressants may prove to be more steroid sparing than cyclosporine alone and promise to increase the safety of steroid-free immunosuppression for renal transplant recipients.
在当今时代，移植界应通过降低心血管风险和最大化患者长期生存率来促进长期移植器官存活，在此背景下，无类固醇免疫抑制仍是一个颇具吸引力的目标。在环孢素时代，在相当一部分少数患者中，停用类固醇的风险超过了其益处。一些新型免疫抑制剂可能比单独使用环孢素更能减少类固醇的使用，并有望提高肾移植受者无类固醇免疫抑制的安全性。
