Bessler W G, Heinevetter L, Wiesmüller K H, Jung G, Baier W, Huber M, Lorenz A R, Esche U V, Mittenbühler K, Hoffmann P
Institut für Immunbiologie der Universität Freiburg, Germany.
Int J Immunopharmacol. 1997 Sep-Oct;19(9-10):547-50. doi: 10.1016/s0192-0561(97)00054-4.
We investigated the immunostimulatory properties of synthetically prepared lipopeptides derived from the cell wall of Gram negative bacteria. These compounds constitute potent macrophage activators and polyclonal B-lymphocyte stimulators. They are also immunoadjuvants in parenteral or oral immunization. By coupling the lipopeptides to haptens or low molecular weight antigens which are not immunogenic per se, highly immunogenic conjugates can be prepared. Lipopeptide antigen conjugates as synthetic vaccines give protection by enhancing the antibody-mediated immune response, and they stimulate the cellular immune response in vivo by priming of cytotoxic T-cells.
我们研究了从革兰氏阴性菌细胞壁合成制备的脂肽的免疫刺激特性。这些化合物是有效的巨噬细胞激活剂和多克隆B淋巴细胞刺激剂。它们也是肠胃外或口服免疫中的免疫佐剂。通过将脂肽与本身无免疫原性的半抗原或低分子量抗原偶联，可以制备出高免疫原性的缀合物。脂肽抗原缀合物作为合成疫苗，通过增强抗体介导的免疫反应提供保护，并且它们通过激活细胞毒性T细胞在体内刺激细胞免疫反应。
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