Lesser R P, Arroyo S, Crone N, Gordon B
Department of Neurology, The Johns Hopkins University School of Medicine, and the Zanvyl Krieger Mind/Brain Institute, Baltimore, Maryland, USA.
Epilepsia. 1998;39 Suppl 4:S69-80. doi: 10.1111/j.1528-1157.1998.tb05127.x.
In patients with intractable epilepsy, surgical resections are performed with the primary goal of improving seizure control. The risk is that the resections may also remove tissues crucial for normal activities. The goal of surgical planning is therefore to determine as accurately as possible the regions of seizure onset and the regions controlling important functions, so that one can determine what to remove and what to leave in place. Clinical functional localization has been performed using cortical stimulation for over half a century, using both intraoperative and extraoperative methods. Signal averaging also has been widely used. More recently, techniques based on analysis of EEG in the frequency domain have shown promise. The methods appear to accurately indicate the function of the region assessed but do not necessarily predict functional consequences of resection. We review these methods, their indications, and the results obtained by their use.
对于难治性癫痫患者，进行手术切除的主要目的是改善癫痫发作的控制情况。风险在于切除操作可能也会移除对正常活动至关重要的组织。因此，手术规划的目标是尽可能准确地确定癫痫发作起始区域和控制重要功能的区域，以便能够确定切除什么以及保留什么。临床功能定位使用皮质刺激法已开展了半个多世纪，采用了术中及术外方法。信号平均法也已得到广泛应用。最近，基于频域脑电图分析的技术显示出了前景。这些方法似乎能准确指示所评估区域的功能，但不一定能预测切除后的功能后果。我们回顾这些方法、它们的适应证以及使用这些方法所获得的结果。
