环境基因组计划：多态性的功能分析
The Environmental Genome Project: functional analysis of polymorphisms.
作者信息
Guengerich F P
机构信息
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.
出版信息
Environ Health Perspect. 1998 Jul;106(7):365-8. doi: 10.1289/ehp.98106365.
Abstract
The ultimate goal of the Environmental Genome Project is the improvement of human health on the basis of information about the variations in certain genes. The first phase of the project will involve the selection of the human genes and characterization of the alleles occurring in the American population. However, intelligent use of this information will require analysis of the relevance of the allelic differences. Epidemiology alone will not solve the problem, and mechanistic studies will be required. Factors to be considered in the design of functional analyses are considered in this commentary.
摘要
环境基因组计划的最终目标是在获取某些基因变异信息的基础上改善人类健康。该计划的第一阶段将包括选择人类基因并对美国人群中出现的等位基因进行特征描述。然而，要明智地利用这些信息，就需要分析等位基因差异的相关性。仅靠流行病学无法解决问题，还需要进行机制研究。本评论探讨了功能分析设计中需考虑的因素。
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