Effect of single and divided dose administration on the pharmacokinetics of albendazole in sheep and goat.

The pharmacokinetics of albendazole were studied in sheep and goats following single and divided dose administration at nematocidal and flukicidal dose rates. The disposition curves of the metabolites indicated increased uptake of the drug both in sheep and goats at divided dose schedules compared to single dose administration (P < 0.05). The increased bioavailability of benzimidazole anthelmintics in divided dose schedules could improve their efficacy and help in extending their lives.