Tarlinton D
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Curr Opin Immunol. 1998 Jun;10(3):245-51. doi: 10.1016/s0952-7915(98)80161-1.
Our understanding of the formation of germinal centers has advanced considerably during the past year. Highlights include the elucidation of the role of cytokines and chemokines in splenic organization and lymphocyte migration and their roles in germinal center development. The functional consequences of recombination-activating gene re-expression in the germinal center have also been reported, as have in vitro models of somatic mutation. Finally the resolution of the germinal center reaction is being addressed by analysis of the individual cell types produced.
在过去的一年里，我们对生发中心形成的理解有了显著进展。其中的亮点包括阐明了细胞因子和趋化因子在脾脏组织和淋巴细胞迁移中的作用，以及它们在生发中心发育中的作用。生发中心中重组激活基因重新表达的功能后果也有报道，体细胞突变的体外模型同样如此。最后，通过对所产生的单个细胞类型的分析，生发中心反应的消退问题也正在得到解决。
