Yokoyama W M
Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St Louis, MO 63110, USA.
Curr Opin Immunol. 1998 Jun;10(3):298-305. doi: 10.1016/s0952-7915(98)80168-4.
In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling cascade; meanwhile, components of the activation cascade are being elucidated, permitting us to integrate the pathways involved.
在杀伤细胞靶标过程中，自然杀伤细胞利用激活它们的受体以及对MHC I类具有特异性的抑制其激活的受体。在理解抑制性受体方面进展迅速，有迹象表明它们可分为两种不同的结构类型，似乎利用相同的抑制性信号传导级联；与此同时，激活级联的组成部分也在被阐明，这使我们能够整合所涉及的途径。
