Peterson E J, Clements J L, Fang N, Koretzky G A
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
Curr Opin Immunol. 1998 Jun;10(3):337-44. doi: 10.1016/s0952-7915(98)80173-8.
Adaptor molecules, proteins that possess no intrinsic enzymatic function, but which mediate protein-protein interactions, have a critical role in integrating signal transduction pathways following engagement of cell-surface receptors. Several newly described adaptor molecules have been shown to serve important functions in the regulation of signaling events initiated by lymphocyte antigen receptors. Understanding how these adaptor proteins function to modulate signaling cascades will provide important insights into the complex biology of lymphocyte activation.
衔接分子是一类本身不具备酶活性功能，但能介导蛋白质-蛋白质相互作用的蛋白质，在整合细胞表面受体激活后的信号转导途径中发挥关键作用。已证实几种新描述的衔接分子在调节淋巴细胞抗原受体引发的信号事件中发挥重要功能。了解这些衔接蛋白如何调节信号级联反应，将为深入认识淋巴细胞激活的复杂生物学机制提供重要线索。
