1995 - 1997年中华人民共和国生物制药分析进展

Advances in biopharmaceutical analysis in the People's Republic of China 1995-1997.

作者信息

Qin Z

机构信息

Department of Pharmaceutical Analysis, School of Pharmacy, Shanghai Medical University, PR China.

出版信息

J Pharm Biomed Anal. 1998 Jun;17(2):183-92. doi: 10.1016/s0731-7085(97)00217-3.

DOI:10.1016/s0731-7085(97)00217-3

PMID:9638571

Abstract

The present paper is the third biannual review in succession to the author's previous publications (Z.L. Qin, Advances in biopharmaceutical analysis in the People's Republic of China: 1991-1993, J. Pharm. Biomed Anal. 13, 1995, 1-7 and Z.L. Qin, Advances in biopharmaceutical analysis in the People's Republic of China: 1993-1995, J. Pharm. Biomed. Anal. 14, 1996, 1395-1403), regarding the methodological study and progress in biopharmaceutical analysis by RP-HPLC, GC and GC-MS selected from relative journals between April 1995 and March 1997 in P.R. China. The published methods were widely adopted in pharmacokinetic and metabolic studies. Investigation on drug metabolism were conducted more deeply, both in vitro and in vivo, for searching the structure of metabolites and drug metabolic pathways. The use of high performance CZE as a new trend for the analysis of drugs and metabolites in biofluids was also reported.

摘要

本文是作者之前发表文章（秦正龙，《中华人民共和国生物药物分析进展：1991 - 1993》，《药物分析杂志》13卷，1995年，第1 - 7页；秦正龙，《中华人民共和国生物药物分析进展：1993 - 1995》，《药物分析杂志》14卷，1996年，第1395 - 1403页）的连续第三次半年回顾，内容涉及1995年4月至1997年3月间从中国相关期刊中选取的关于反相高效液相色谱（RP - HPLC）、气相色谱（GC）和气相色谱 - 质谱联用（GC - MS）在生物药物分析方面的方法学研究与进展。所发表的方法在药代动力学和代谢研究中得到广泛应用。为探寻代谢物结构和药物代谢途径，对药物代谢进行了更深入的体内外研究。还报道了将高效毛细管电泳（CZE）作为生物流体中药物和代谢物分析新趋势的应用情况。