Flow-injection spectrophotometric determination of diclofenac sodium in pharmaceuticals and urine samples.

作者信息

García M S, Albero M I, Sánchez-Pedreño C, Molina J

机构信息

Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.

出版信息

J Pharm Biomed Anal. 1998 Jun;17(2):267-73. doi: 10.1016/s0731-7085(97)00195-7.

A sensitive and fast flow-injection spectrophotometric method for the determination of diclofenac sodium based on the formation of coloured compound with Ce(IV)-3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in H2SO4 3 x 10(-2) M medium is proposed. Using the peak height as a quantitative parameter diclofenac was determined at 580 nm over the range 0.20-8.0 micrograms ml-1. The proposed method was successfully applied to the determination of diclofenac in pharmaceuticals and urine samples.