Castriota-Scanderbeg A, Sacco M C, Emberti-Gialloreti L, Fraracci L
Department of Radiology, S. Lucia Scientific Institute, Rome, Italy.
Skeletal Radiol. 1998 May;27(5):271-7. doi: 10.1007/s002560050380.
To compare the performance of a new sonographic (US) method of bone age estimation with other methods currently in use.
One hundred and fifteen subjects underwent left hand/wrist radiography and US examination of the hip for bone age assessment. For each patient, measurements of skeletal age were available based on Greulich-Pyle and Tanner and Whitehouse, the latter being presented in three subtypes (RUS, carpals, and B20) in addition to the US values. To assess agreement between methods, each method was compared with every other method. Differences between calculated skeletal age and chronological age were assessed, and the sensitivity, specificity, and predictive values of each method computed.
Coupled B20/RUS values showed the best agreement, with 95% of observations within 2.45 years of each other, followed by carpals/B20, B20/GP, and GP/RUS. The US method agreed the least (difference of 4.19-5.13 years) with the other methods. The US method provided 85.8% (US vs RUS) to 91.3% (US vs GP) concordant results in recognizing differences between skeletal and chronological age, and showed a 72.5% sensitivity and a 56.8% specificity.
Although the US method promises to permit a safe and cost-effective assessment of skeletal age, its low accuracy makes it currently unsuitable for clinical use.
比较一种新的超声（US）骨龄评估方法与目前使用的其他方法的性能。
115名受试者接受了左手/腕部X线摄影及髋部超声检查以评估骨龄。对于每位患者，基于格鲁利希-派尔法和坦纳及怀特豪斯法可获得骨骼年龄测量值，除了超声值外，后者还呈现三种亚型（桡尺骨远端、腕骨和B20）。为评估各方法之间的一致性，将每种方法与其他方法进行比较。评估计算出的骨骼年龄与实际年龄之间的差异，并计算每种方法的敏感性、特异性和预测值。
联合的B20/桡尺骨远端值显示出最佳的一致性，95%的观察值彼此相差在2.45年以内，其次是腕骨/B20、B20/格鲁利希-派尔法和格鲁利希-派尔法/桡尺骨远端。超声方法与其他方法的一致性最差（相差4.19 - 5.13年）。超声方法在识别骨骼年龄与实际年龄差异方面提供了85.8%（超声法与桡尺骨远端法比较）至91.3%（超声法与格鲁利希-派尔法比较）的一致结果，敏感性为72.5%，特异性为56.8%。
尽管超声方法有望实现安全且经济高效的骨龄评估，但其低准确性使其目前不适用于临床应用。
