Baan C C, Weimar W
Department of Internal Medicine I, University Hospital Rotterdam-Dijkzigt, The Netherlands.
Transpl Int. 1998;11(3):169-80. doi: 10.1007/s001470050124.
As our knowledge of the cytokine network in experimental transplant models grows, we need to understand how and to what extent cytokines mediate the various donor-directed immune events in clinical situations. This overview of clinical cytokine measurements shows that specific intragraft cytokine messenger RNA (mRNA) expression profiles can be associated with acute rejection, that they may reflect the efficacy of immunosuppression, and that they can identify patients at risk for the development of early chronic rejection. The literature also shows that acute rejection and immunological quiescence in humans are not restricted to the cytokine patterns defined in the type 1/type 2 paradigm. This apparent lack of association may be caused by the immunosuppression used in the clinic but may also be the result of the infinite diversity of donor and recipient factors, in which polymorphisms in cytokines and cytokine receptor genes may play a central role.
随着我们对实验性移植模型中细胞因子网络的了解不断增加，我们需要明白细胞因子如何以及在何种程度上介导临床情况下各种针对供体的免疫事件。对临床细胞因子测量的这一概述表明，特定的移植内细胞因子信使核糖核酸（mRNA）表达谱可能与急性排斥反应相关，它们可能反映免疫抑制的疗效，并且能够识别有早期慢性排斥反应发生风险的患者。文献还表明，人类的急性排斥反应和免疫静止并不局限于1型/2型范式中所定义的细胞因子模式。这种明显缺乏关联的情况可能是由临床使用的免疫抑制导致的，但也可能是供体和受体因素无限多样性的结果，其中细胞因子和细胞因子受体基因的多态性可能起着核心作用。
