Kirov R, Moyanova S
Institute of Physiology, Bulgarian Academy of Science, Sofia.
Int J Neurosci. 1998 Apr;93(3-4):265-78. doi: 10.3109/00207459808986432.
The age-related effect of the specific 5-hydroxytryptamine-2A/2C (5-HT(2A/2C)) antagonist ritanserin at two doses 0.63 mg/kg and 2.5 mg/kg) on six sleep-waking phases in young, middle-aged, and old male Wistar rats was electroencephalographically (EEG) examined. Only in the young and middle-aged rats, ritanserin enhanced slow wave sleep and reduced wakefulness in a dose-dependent manner. Ritanserin suppressed paradoxical sleep, such that this effect did not depend on the age. Although the effect of ritanserin on slow wave sleep was significantly smaller in the old compared to the young and the middle-aged rats, ritanserin produced an apparent sleep-improving effect in the old age group.
采用脑电图（EEG）检查特定5-羟色胺-2A/2C（5-HT(2A/2C)）拮抗剂利坦色林（0.63毫克/千克和2.5毫克/千克两种剂量）对年轻、中年和老年雄性Wistar大鼠六个睡眠-觉醒阶段的年龄相关影响。仅在年轻和中年大鼠中，利坦色林以剂量依赖方式增强慢波睡眠并减少觉醒。利坦色林抑制快速眼动睡眠，且这种作用不依赖于年龄。尽管与年轻和中年大鼠相比，利坦色林对老年大鼠慢波睡眠的影响显著较小，但利坦色林在老年组中产生了明显的改善睡眠作用。
