[The mechanisms of progesterone treatment on endometrial carcinoma].

OBJECTIVE

To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma.

METHODS

We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy.

RESULTS

The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells.

CONCLUSIONS

Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.