Chen C, Hua Z, Jin X
Shanghai Ruijin Hospital.
Zhonghua Fu Chan Ke Za Zhi. 1997 Jul;32(7):415-7.
To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma.
We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy.
The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells.
Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.
研究外源性孕激素治疗子宫内膜癌的机制。
用光镜和电镜观察外源性孕激素处理后的子宫内膜癌细胞的形态学变化。
处理后的肿瘤细胞主要变化为分化良好、分泌活性增加及肿瘤细胞凋亡。
孕激素可能直接作用于肿瘤细胞，抑制肿瘤细胞生长并导致分化良好。临床上术前及术后应用孕激素治疗，可减少腹膜种植和转移，也可降低术后复发率。
