Wu X, Lu K, Su Y
Nanjing Jinling Hospital.
Zhonghua Fu Chan Ke Za Zhi. 1997 Jul;32(7):428-31.
To investigate the relationship between renin-angiotensin system (RAS) and polycystic ovarian syndrome (PCOS) METHODS: A pituitary-stimulating test with luteinizing hormone releasing hormone (LRH, 100 micrograms) was performed in two PCOS groups with similar mean testosteron (T) levels of luteinizing hormone/follicular stimulating hormone (LH/FSH) (LH/FSH > or = 3, group 1, n = 15; LH/FSH < 3, group 2, n = 15) and the controls (n = 20) of matched body mass index with group 1. The basal level and LRH-evoked responses of LH, plasma renin activity (PRA), angiotensin II (AT II ) and aldosterone (ALD) were measured by RIA with commercially available kits. In the basal state, a positive correlation was found between T and AT II levels (r = 0. 49, P < 0.05) in all PCOS subjects. After LRH administration, susceptible individuals, especially of group 1 had exaggerated responses of LH, PRA, AT II and ALD as compared with the controls, and a positive correlation was also found between peak levels of LH and AT II (r = 0.54, P < 0.01).
There is enhanced RAS function in PCOS especially in group 1. This may contribute to the excess androgen production and high incidence of ovarian hyperstimulation syndrome in this disorder.
研究肾素 - 血管紧张素系统（RAS）与多囊卵巢综合征（PCOS）之间的关系。方法：对两组多囊卵巢综合征患者进行促垂体试验，给予促黄体生成素释放激素（LRH，100微克）。这两组患者的平均睾酮（T）水平及促黄体生成素/促卵泡生成素（LH/FSH）比值相近（LH/FSH≥3，第1组，n = 15；LH/FSH < 3，第2组，n = 15），对照组（n = 20）的体重指数与第1组匹配。采用市售试剂盒通过放射免疫分析法测定LH、血浆肾素活性（PRA）、血管紧张素II（AT II）和醛固酮（ALD）的基础水平及LRH激发后的反应。在基础状态下，所有PCOS患者中T与AT II水平呈正相关（r = 0.49，P < 0.05）。给予LRH后，易感个体，尤其是第1组患者，与对照组相比，LH、PRA、AT II和ALD的反应增强，且LH峰值与AT II之间也呈正相关（r = 0.54，P < 0.01）。结论：PCOS患者尤其是第1组患者的RAS功能增强。这可能导致该疾病中雄激素产生过多以及卵巢过度刺激综合征的高发病率。
