[上皮性卵巢癌的治疗与预后因素]

Gynecology Oncology Center, People's Hospital of Beijing Medical University.

Zhonghua Fu Chan Ke Za Zhi. 1997 Aug;32(8):476-9.

OBJECTIVE

To study the treatment results and prognostic factors of epithelial ovarian carcinoma.

METHODS

Retrospective study of 155 cases of ovarian epithelial carcinoma admitted in our hospital since Jan. 1970 to Dec. 1992. All of these cases had postoperative pathological diagnosis and staging according to FIGO. 42 cases had second operations and 4 cases had the third. 149 cases had postoperative chemotherapies except for 6. Chemotherapies were also given to 32 cases after the second operation, while 9 for recurrence.

RESULTS

The 2-year, 5-year, 10-year survival rates of stage I were 92.4%, 87.0%, 70.6%; and II 91.9%, 63.6% 47.8%; III 59.9%, 38.2%, 19.2% and IV 25.0%, 25.0%, 0.0% respectively. All 6 cases without chemotherapy after surgery died within 2 years. The results indicated that the prognosis of ovarian epithelial carcinoma was related to clinical stage, cellular grade and tumor residues. The 5-year survival rates for stage I was 87.0% and III 38.2% (P < 0.001); and cell G1 95.0% and G3 11.8% (P < 0.001), while no residual tumor 97.6% and with residual tumor > 2cm 21.2% (P < 0.001) respectively.

CONCLUSION

Residual tumor of ovarian epithelial carcinoma < 2cm after primary surgery and chemotherapy right after surgery can improve survival rates.

目的

研究上皮性卵巢癌的治疗效果及预后因素。

方法

回顾性分析1970年1月至1992年12月我院收治的155例卵巢上皮癌患者。所有病例均有术后病理诊断，并根据国际妇产科联盟（FIGO）进行分期。42例行二次手术，4例行三次手术。149例术后接受化疗，6例未化疗。32例二次手术后接受化疗，9例复发后接受化疗。

结果

Ⅰ期患者的2年、5年、10年生存率分别为92.4%、87.0%、70.6%；Ⅱ期分别为91.9%、63.6%、47.8%；Ⅲ期分别为59.9%、38.2%、19.2%；Ⅳ期分别为25.0%、25.0%、0.0%。所有6例术后未化疗患者均在2年内死亡。结果表明，卵巢上皮癌的预后与临床分期、细胞分级及肿瘤残留有关。Ⅰ期患者5年生存率为87.0%，Ⅲ期为38.2%（P<0.001）；细胞G1级为95.0%，G3级为11.8%（P<0.001）；无残留肿瘤者为97.6%，残留肿瘤>2cm者为21.2%（P<0.001）。