[甲胎蛋白、游离雌三醇、β-人绒毛膜促性腺激素水平在唐氏综合征产前诊断中的应用]
[AFP, uE3, beta-hCG levels applied for prenatal diagnosis of Down's syndrome].
作者信息
Liao S, Wang Y, Ye G
机构信息
Institute of Medical Genetics, People's Hospital of Henan Province, Zhengzhou.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 1997 Nov;32(11):655-8.
OBJECTIVE
To investigate the relationship between fetal trisomy 21 and alpha fetoprotein (AFP), unconjugated oestriol (uE3) and beta human chorionic gonadotropin (beta-hCG) levels in maternal serum, amniotic fluid and fetal serum.
METHOD
AFP, uE3 and beta-hCG levels in maternal serum, amniotic fluid and fetal serum from 17 pregnancies with fetal trisomy 21 and 131 unaffected control pregnancies were measured between 16 to 28 weeks gestation using radioimmunoassay.
RESULTS
In these pregnancies with fetal trisomy 21, the AFP and uE3 levels in maternal serum, amniotic fluid and fetal serum were lower than those in controls; but beta-hCG levels were higher (P < 0.05).
CONCLUSION
To measure maternal serum AFP, uE3 and beta-hCG levels will be useful in prenatal detection of trisomy 21.
目的
探讨胎儿21三体与母血清、羊水及胎儿血清中甲胎蛋白（AFP）、非结合雌三醇（uE3）和β-人绒毛膜促性腺激素（β-hCG）水平之间的关系。
方法
采用放射免疫分析法，对17例胎儿21三体妊娠孕妇及131例未受影响的对照妊娠孕妇在妊娠16至28周期间的母血清、羊水及胎儿血清中的AFP、uE3和β-hCG水平进行了测定。
结果
在这些胎儿21三体妊娠中，母血清、羊水及胎儿血清中的AFP和uE3水平低于对照组；但β-hCG水平较高（P<0.05）。
结论
检测母血清AFP、uE3和β-hCG水平对21三体的产前诊断有帮助。
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