[系统性红斑狼疮合并妊娠患者外周血T淋巴细胞亚群及血清白细胞介素-2受体的变化]
[The changes of T lymphocyte subsets and serum interleukin-2 receptor in peripheral blood of the pregnant women complicated by systemic lupus erythematosus].
作者信息
Su Y, Hong S, Zhao A
机构信息
Renji Hospital, Shanghai Second Medical University.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 1997 Nov;32(11):671-3.
OBJECTIVE
To determine the changes of T lymphocyte subsets, natural killer (NK) cell and serum interleukin-2 receptor (SIL-2R) in peripheral blood of the pregnant women with systemic lupus erythematosus (SLE).
METHODS
T lymphocyte subsets NK cell, and SIL-2R in peripheral blood were detected by flow cytometry (FCM) and enzyme-labeled immunosorbent assay (ELISA) in 14 cases of pregnant women complicated by SLE (SLE+NP), 18 cases of stationary phase SLE (SLE), 20 cases of normal non-pregnant women (NNP) and 20 cases of normal pregnant women (NP).
RESULTS
The percentages of CD4+ cell were decreased significantly in SLE+NP group as compared with the other three groups (P < 0.01); and the ratio of CD4+/CD8+ was decreased significantly in SLE+NP group, as compared that in SLE group and in NNP group (P < 0.01). There were no difference in the number of NK cells among the four groups. The SIL-2R values were found to be increased significantly in the SLE+NP group, as compared with that of other three groups (P < 0.01).
CONCLUSION
The observation on the changes of peripheral T lymphocyte subsets and SIL-2R may be helpful for monitoring progress of SLE during pregnancy.
目的
探讨系统性红斑狼疮（SLE）孕妇外周血T淋巴细胞亚群、自然杀伤（NK）细胞及血清白细胞介素-2受体（SIL-2R）的变化。
方法
采用流式细胞术（FCM）和酶联免疫吸附试验（ELISA）检测14例合并SLE的孕妇（SLE+NP）、18例静止期SLE患者（SLE）、20例正常未孕妇女（NNP）及20例正常孕妇（NP）外周血T淋巴细胞亚群、NK细胞及SIL-2R。
结果
SLE+NP组CD4+细胞百分比显著低于其他三组（P<0.01）；SLE+NP组CD4+/CD8+比值显著低于SLE组和NNP组（P<0.01）。四组NK细胞数量无差异。SLE+NP组SIL-2R值显著高于其他三组（P<0.01）。
结论
观察外周血T淋巴细胞亚群及SIL-2R变化有助于监测SLE孕妇病情进展。
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