Gene therapy in autoimmune diseases.
作者信息
Evans C H, Whalen J D, Evans C H, Ghivizzani S C, Robbins P D
机构信息
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, PA, USA.
出版信息
Ann Rheum Dis. 1998 Mar;57(3):125-7. doi: 10.1136/ard.57.3.125.
Abstract
摘要
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Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10.通过基因改造的造血细胞组成性全身表达白细胞介素-1受体拮抗剂（IL-1Ra）或可溶性肿瘤坏死因子受体，可抑制脂多糖诱导的白细胞介素-6（IL-6）和白细胞介素-10（IL-10）的产生。
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